Researchers have cracked the mystery behind how the Botulinum neurotoxin type-A, also known as Botox, infiltrates neurons. The toxin utilizes a small complex formed by a receptor called Synaptotagmin 1, along with two other clostridial neurotoxin receptors, to enter synaptic vesicles in neurons. This infiltration interrupts nerve-to-muscle communication, leading to paralysis.
Researchers have cracked the mystery behind how the Botulinum neurotoxin type-A, also known as Botox, infiltrates neurons. The toxin utilizes a small complex formed by a receptor called Synaptotagmin 1, along with two other clostridial neurotoxin receptors, to enter synaptic vesicles in neurons. This infiltration interrupts nerve-to-muscle communication, leading to paralysis.
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